Bioreactors

This book presents the design, fabrication, and control of a new type of bioreactor meant especially for animal cell line culture. The new bioreactor, called the "see-saw bioreactor," is ideal for the growth of cells with a sensitive membrane. The authors describe the principle of operation and how to automatically control the bioprocess.

Introduction A new type of bioreactor Bioreactor modeling and control Organization of the book Novel see-saw bioreactor Construction and working of the see-saw bioreactor Theoretical modeling and simulation Oxygen transfer to the falling film Oxygen transfer to the flat surface Total oxygen transfer in the bioreactor Experiments to verify the modeling Discussion of the results Future scope of work Simulation of bioprocess and development of BIPROSIM: A general purpose simulation program Mathematical formulation of the bioprocess Modes of operation Adoption in the model parameters The algorithm of BIPROSIM Sample run Dynamic optimization of a bioprocess using genetic algorithm Historical background Bioprocess model development Application of genetic algorithm for control input optimization Explanation of the application of GA Algorithm 4.1 Flowchart of Algorithm 4.1 Subroutine "Child" Subroutine "Mutate" Algorithm 4.2 Flowchart of Algorithm 4.2 Results of the application of GA Bioprocesses and time delay control The problem of bioprocess control Development of dynamic model Time delay control Time delay controller as bioprocess controller Observer design PID controllers for bioprocess control Simulation results and discussions Experimentation on the bioreactor Instrumentation Experimentation Presentation of experimental results Comparison between experimental and theoretical results Summary General conclusion and future scope of research Overview of the work General conclusion Future scope of research References Appendix: Environmental control and sterilization of the bioreactor