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Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Prod

Author: Taro Noguchi

Publishing date: 2018

This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry. Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested only natural products bearing one stereochemistry available in nature. As

455.00 zł

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Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Prod