Viruses & the Nucleus

Interdisciplinary in approach, this definitive text on viral/nuclear interactions illustrates how viruses (positive and negative DNA and RNA) interact with the nucleus and its components to further viral replication, and the resulting consequences for the host cell.

Preface. Contributors. 1. The Nucleus - An Overview (Dean A. Jackson). 1.1 Introduction. 1.2 The gene expression pathway in mammalian cells. 1.3 Chromosome structure and DNA loops. 1.4 Duplicating the genetic code. 1.5 Nuclear Compartmentalization. 1.6 Nuclear Architecture - implications for viral infections. 1.7 Conclusion. References. 2. The Eukaryotic Cell Cycle (Jane V. Harper and Gavin Brooks). 2.1 Introduction. 2.2 The G0/G1 transition. 2.3 The G1-S transition. 2.4 S Phase. 2.5 The G2-M transition. 2.6 Mitosis (M-Phase). 2.7 Cytokinesis. 2.8 Endoreduplication. 2.9 Summary and Conclusions. References. 3. DNA Viruses and the Nucleus (G. Eric Blair and Nicola James). 3.1 Introduction. 3.2 The structure of the nucleus. 3.3 DNA Viruses and the nucleus. 3.4 Concluding comments and future directions. References. 4. Retroviruses and the nucleus (Carlos De Noronha and Warner C. Greene). 4.1 Retroviral structure. 4.2 The retroviral life cycle. 4.3 Entering the nucleus. 4.4 Inside the nucleus. 4.5 Leaving the nucleus and the cell. 4.6 Future Perspectives. References. 5. Negative-sense RNA Viruses and the Nucleus (Debra Elton and Paul Digard). 5.1 Introduction. 5.2 The necessity of a nucleus. 5.3 Nuclear import machinery. 5.4 The cellular transcription machinery. 5.5 Nuclear architecture. 5.6 Nuclear export. 5.7 Evasion of innate antiviral responses. References. 6. Positive-Strand RNA Viruses and the Nucleus (Kurt E. Gustin and Peter Sarnow). 6.1 Introduction. 6.2 Replication of positive-strand RNA viruses in enucleated cells. 6.3 Localization of viral proteins to the nucleus. 6.4 Interaction of nuclear factors with viral proteins and nucleic acids. 6.5 Cytoplasmic accumulation of nuclear proteins during infection. 6.6 Disruption of nucleo-cytoplasmic trafficking by positive-strand RNA viruses. 6.7 Advantages provided to the virus by inhibiting nuclear import. 6.8 Conclusions. References. 7. Viruses and the Nucleus (David A. Matthews and Julian A. Hiscox). 7.1 Introduction. 7.2 Techniques used to examine the nucleolus. 7.3 Nucleolar localization signals (NoLS). 7.4 Viral interactions with the nucleolus. 7.5 The nucloelus, viruses and autoimmunity. 7.6 Summary. References. 8. Virus Interactions with PML Nuclear Bodies (Keith N. Leppard and John Dimmock). 8.1 Introduction. 8.2 ND10 in uninfected cells. 8.3 Functions of ND10. 8.4 ND10 and virus infection. 8.5 Why do viruses interact with and modify ND10?. References. 9. Viruses and the Cell Cycle (Crisanto Gutierrez, Brian Dove and Julian A. Hiscox). 9.1 Introduction: An the overview of the eukaryotic cell cycle. 9.2 Retroviruses and the cell cycle. 9.3 RNA viruses and the cell cycle. 9.4 Viruses, the nucleolus and cell cycle control. 9.5 Viral interaction with aviator protein-1 (AP-1). 9.6 Summary. References. Index.