This book is a comprehensive text covering the research and development trends in the booming field of transition metal catalyzed oxidative cross-coupling reactions. Oxidative cross-coupling reaction is a new method to forming chemical bonds besides the traditional cross-coupling reactions. This book provides the answers to how this coupling reaction occurs and what its advantages are. The palladium, copper and iron catalyzed oxidative cross-coupling reactions as the main focuses of interest are described in detail. The oxidative cross-coupling reactions catalyzed by other metals and transition-metal-free oxidative coupling reactions are also introduced.This book provides a useful reference source for researchers and graduates in the field of transition metal catalyzed
This unique handbook provides pediatric and adult endocrinologists and multidisciplinary clinical care providers a guide to transition from pediatric to adult care and an understanding of developmental and psychosocial issues of young adulthood and how they relate to healthcare and disease self-management. The handbook is divided into two parts. Part one describes transition interventions and novel strategies that can be integrated into routine care and gives practical considerations for transition processes from both the pediatric and adult perspectives, with applications across multiple endocrine conditions. Part two focuses on transition issues specific to common endocrine conditions - type 1 and type 2 diabetes, Turner syndrome, congenital adrenal hyperplasia,
This thesis experimentally demonstrates the much discussed electronic charge-glass states in solids. It focuses on quasi-two-dimensional organic conductors of the th-(BEDT-TTF)2X family, which form anisotropic triangular lattices, and examines their electronic properties using various measurements: resistivity, time-resolved electric transport, X-ray diffraction analysis, and nuclear magnetic resonance spectroscopy. The hallmark of the charge glass caused by geometrical frustration of lattice structure for those materials is successfully observed for the first time. The thesis provides new insights into the exotic properties of matter driven by strong electron correlations and crystalline frustration. The introduction enables beginners to understand fundamentals of the
Progress in basic and clinical immunology within the last two decades has provided profound insight into the immune system and its role in preventing endogenous and exogenous damage. In contrast, disbalances within this system can result in autoimmune disorders which may affect diverse organs and result in distinct clinical pictures. In many of these, however, the individual etiopathogenetic mechanisms are poorly understood and even more their clinical symptoms are hard to treat.The book offers insight into basic mechanisms of autoimmune disorders. It includes neurological, gastrointestinal, ophthalmological and skin diseases as well as current and future therapeutic options including immunomodulatory drugs and different vaccination strategies. By addressing diverse
This book presents experimental results and theoretical advances in the field of ultra-low-cycle fatigue failure of metal structures under strong earthquakes, where the dominant failure mechanism is ductile fracture.
This book presents the latest research in ultrathin carbon-based protective overcoats for high areal density magnetic data storage systems, with a particular focus on hard disk drives (HDDs) and tape drives. These findings shed new light on how the microstructure and interfacial chemistry of these sub-20 nm overcoats can be engineered at the nanoscale regime to obtain enhanced properties for wear, thermal and corrosion protection - which are critical for such applications. Readers will also be provided with fresh experimental insights into the suitability of graphene as an atomically-thin overcoat for HDD media. The easy readability of this book will appeal to a wide audience, ranging from non-specialists with a general interest in the field to scientists and industry
This book offers up-to-date information on different microbiomes, their community composition and interactive functions with the host, bringing together information from diverse research reports to provide an overview of the rapid developments in meta-omics technologies. It is a valuable resource for scientists, researchers, postgraduate and graduate students interested in understanding the impact and importance of next generation sequencing technologies on different hosts and their microbiomes.
This book thoroughly describes a theory concerning the yield and failure of materials under multi-axial stresses - the Unified Strength Theory, which was first proposed by the author and has been frequently quoted since. It provides a system of yield and failure criteria adopted for most materials, from metals to rocks, concretes, soils, and polymers. This new edition includes six additional chapters: General behavior of Strength theory function; Visualization of the Unified Strength Theory; Equivalent Stress of the UST and Comparisons with other criteria; Economic Signification of the UST; General form of failure criterion; Beauty of Strength Theories. It is intended for researchers and graduate students in various fields, including engineering mechanics, material
This book presents up-to-date, practically oriented information on major topics in acute hepatitis. The coverage encompasses epidemiology; diagnosis, including molecular methods; treatment and challenges; and the management of co-infections. The book opens by examining the local and global epidemiology of acute hepatitis. Detailed attention is then paid to each of acute hepatitis A, acute hepatitis B, acute hepatitis C, hepatitis D co-infection, and hepatitis E. Acute Hepatitis will be of high value for general practitioners and specialists in gastroenterology, infectious diseases, and internal medicine. It will be international in scope in terms of both authorship and appeal.
This volume focuses on virus-host cell interactions, cellular genes acquired or modulated by viruses, the pathological effects of these interactions, and therapeutic interventions. Several chapters specifically address the role of viruses and genes - such as oncogenes, proto-oncogenes, or tumor suppressor genes - in the etiology of human cancer. Oncogenic signaling by PI3 kinase, mTOR, Akt, or the major cancer drivers MYC and RAF, and the role of tumor suppressors like p53, are discussed in detail. The volume also explores the emerging role of noncoding RNAs such as microRNAs in tumorigenesis and cancer therapeutics, and offers new insights into the role of HIV-host interactions relevant to pathogenesis and treatment. Gathering contributions written by leading
Covers viscosities of pure organic liquids and binary liquid mixtures at different temperatures and pressures including organic liquids, organometallic liquids, and organononmetallic liquids and their mixtures.
Visualization technology has become a crucial component of medical and b- medical data processing and analysis. This technology complements tra- tional image processing methods as it allows scientists and practicing medical doctors to visually interact with large, high-resolution three-dimensional - age data. Further, an ever increasing number of new data acquisition me- ods is being used in medicine and the life sciences, in particular in genomics and proteomics. The book contains papers discussing some of the latest data processing and visualization techniques and systems for e?ective analysis of diverse, large, complex, and multi-source data. Internationally leading experts in the area of data visualization came - gether for a workshop dedicated to visualization in
This book presents recent lessons learned in the context of research and development for various dryland ecosystems, focusing on water resources management, land and vegetation cover degradation and remediation, and socioeconomic aspects, as well as integrated approaches to ensuring water and land security in view of the current and predicted climate change. As water and land are the essential bases of food production, the management of these natural resources is becoming a cornerstone for the development of dryland populations. The book gathers the peer-reviewed, revised versions of the most outstanding papers on these topics presented at the ILDAC2015 Conference in Djerba, Tunisia.
Based on the suggestions made by the speakers of Plenary Session IV "Ch- lenges to the management of water resources and to countering deserti cation in the Mediterranean region" during the 15th Economic and Environmental Forum, the OCEEA proposed to organize a workshop on "Water Scarcity, Land Degra- tion and Deserti cation in the Mediterranean region - Environment and Security Aspects". In order to build on common synergies, OSCE sought co-operation with c- leagues from NATO, in particular from the Science for Peace and Security P- gramme. NATO has a longstanding expertise on the issue and had organised in Valencia, in December 2003, a NATO scienti c workshop on "Deserti cation and Security in the Mediterranean Region". The objective of the new proposed wo- shop
This book presents machine learning as a set of pre-requisites, co-requisites, and post-requisites, focusing on mathematical concepts and engineering applications in advanced welding and cutting processes. It describes a number of advanced welding and cutting processes and then assesses the parametrical interdependencies of two entities, namely the data analysis and data visualization techniques, which form the core of machine learning. Subsequently, it discusses supervised learning, highlighting Python libraries such as NumPy, Pandas and Scikit Learn programming. It also includes case studies that employ machine learning for manufacturing processes in the engineering domain. The book not only provides beginners with an introduction to machine learning for applied
