Nanomedicines and Nanoproducts

Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body provides a detailed overview of the disposition of nanoproducts within the body, with a special focus on the respiratory and olfactory routes of nanoproduct administration, buccal exposure and the ingestion of nanoproducts, the integumentary system (formed by the skin, hair, nails, and associated glands), the ocular route, the systemic route, and toxicology as it relates to the nanoscale world. Offering an interdisciplinary, big-picture view of the current and future state of nanotechnology, this book: Identifies key points for the entry of nanoproducts, nanomedicines, and other nanoscale structures into the body Reviews the bodily administration and subsequent disposition of nanoproducts via various exposure routes Describes the intravenous route of administration for the therapeutic management of ocular disease Discusses practical nanoproduct and nanomedicine applications, disposition, and toxicology Summarizes various toxicological principles and the testing of nanoproducts Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body addresses the scope of practical nanoparticle applications in academic research as well as industrial investigation, where "practical" is defined as advantageous in all aspects of nanoproduct disposition, efficacy, and toxicology. The book's goal is to introduce potentially beneficial applications and exciting topics regarding nanoproducts to a variety of professional and general readers. "... a comprehensive text for all nanoscientists ... [that] deals extensively with nanoparticles ranging from organic (liposomes, micelles, and nanocrystals) to nondegradable organic (carbon nanotube) and inorganic (gold, silver, and titanium), and is very useful to understand widely the drug delivery systems of nanoparticles." -Kazuhiro Kagami, Activus Pharma Co., Ltd., Tokyo, Japan

Nanoscale World Scope of Nanoproducts Disposition of Nanoproducts and Nanoparticles Polydispersity of Nanoparticles and Penetration Barriers in the Body Physicochemical Properties of Nanoparticles History of Nanotechnology and Nanomedicine Overview of the Nanoscale World References Overview of Nanoproduct Disposition Pathways for Nanoproduct Absorption, Distribution, and Excretion Liberation, Absorption, Distribution, Metabolism, and Excretion Liberation Bioavailability Volume of Distribution Clearance References Respiratory and Olfactory Routes Anatomy and Physiology Practical Application of Biodegradable Nanomedicines Practical Application of Nonbiodegradable Nanomedicines Inhalation of Nanoproducts Transport and Liberation of Inhaled Products Absorption via the Alveoli Distribution and Translocation Disposition of Nanomedicines from the Nasal Cavity to Systemic Tissues Clearance of Nanoparticles Nanoscale World according to the Respiratory and Olfactory Routes References Buccal Route and Ingestion Anatomy and Physiology Factors Affecting Nanoparticle Disposition Practical Applications of Nanoproducts Risks and Benefits of Nanoscale Food Packaging Products and Nanofoods Bioavailability of Nanomedicines and Nanofoods Cellular Endocytosis of Nanoparticles Disposition of Nanoparticles Following Oral Administration Nanoscale World via the Buccal Route and Ingestion References The Integumentary System and the Ocular Route Anatomy and Physiology Practical Applications in Skin Care Practical Applications in Ocular Medical Care Exposure to Sunlight and Nanoparticle Toxicity Factors Affecting Permeability and Disposition in the Integumentary System Nanoscale World via the Integumentary System and the Ocular Route References Systemic Route Anatomy and Physiology Pathway from Systemic Exposure to Local Delivery Endocytosis of Nanoparticles Nuclear Transport Cell Transition/Translocation Practical Application of Nanomedicines Engineering of Nanomedicines Engineering of Nanoproducts Targeting Disease Nanoscale World via the Systemic Route References Toxicology in the Nanoscale World Characteristics of Exposure Spectrum of Undesired Effects Tolerance Dose-Response Relationships Descriptive Animal Toxicity Tests Nanoproduct Compatibility with the Immune System References