Esmo Handbook on Treatment Evaluation in Cancer

An informative handbook on the staging of cancer and the selection and evaluation of cancer treatment. ESMO Handbook on Treatment Evaluation in Cancer is an ideal resource for medical oncologists and those involved in screening and chemotherapy programs. The text demonstrates how to judge various prognostic and predictive factors, how to determine the relevance of staging, and how to measure patient response for each cancer type. Written by an international team of experts, this progressive text incorporates the fast-moving world of research into the field of cancer genetics and prevention. Topics discussed include: epidemiology genetics of cancer sporadic cancers hereditary cancers primary prevention of cancer screening programmes for the general population screening programmes for those at higher risk the role of prevention secondary prevention of cancer

Introduction Pathology Introduction Aims in diagnosis and treatment Clinical implications and use Biomarkers in oncology Introduction Clinically useful tumor markers "Omics" Conclusions Radiological imaging Introduction Plain X rays Ultrasound Computed tomography Magnetic resonance imaging Newer techniques Nuclear medicine imaging Introduction Positron emission tomography Staging procedures Aim of staging procedures Relevant staging procedures in daily clinical practice Head and neck tumors Small cell lung cancer Non-small cell lung cancer Esophageal cancer Gastric cancer Colorectal cancer Breast cancer Prostate cancer Bladder cancer Renal cell cancer Endometrial cancer Ovarian cancer Malignant melanoma Non-Hodgkin's lymphoma Hodgkin's disease Prognostic criteria Introduction Patient-related prognostic factors Tumor-related prognostic factors Conclusion Predictive tumor markers Introduction Tumor markers: definition and types Tumor markers: evaluation of their clinical utility Tumor markers: methodological, statistical, and reporting considerations Predictive tumor markers in routine use or in development Conclusion Factors determining anticancer treatment Introduction Disease-related factors Patient-related factors Treatment-related factors Sociocultural factors Conclusion Treatment evaluation of activity: From global to personalized approach Introduction Evaluation of the treatment of solid tumors Acute and subacute toxicities of medical anticancer treatment Introduction Tissue necrosis and phlebitis Nausea and vomiting Hypersensitivity reactions Tumor lysis syndrome Flu-like syndrome Hematologic toxicity Mucositis (stomatitis, diarrhea) Hair loss Skin toxicity Pancreatitis Liver toxicity Constipation and ileus Early-onset pulmonary toxicity Metabolic complications Late toxicity Introduction Methodological aspects Second cancer Cardiovascular disease Endocrine effects Other long-term effects Conclusion Acute and late effects in radiation oncology and surgery Introduction Radiotherapy Surgery Psychosocial effects of cancer and treatment Introduction Psychosocial consequences Long-term survivorship Vulnerable cancer patients The role of the psychologist in oncology The role of the oncologist Psychological screening Conclusion Incapacity due to cancer and cancer therapy Introduction General weakness and fatigue Cognitive and emotional impairment Neuropathy Gastrointestinal impairment Bladder disorders Sexual dysfunction Conclusion Reintegration into the workplace Introduction Guidelines for integration Barriers for reintegration into the workplace Requalification and job applications Retirement Conclusion Quality of life issues Introduction HRQOL in clinical trials: design and its impact on clinical results Using HRQOL measures in daily clinical practice: clinical impact Conclusion Conclusion