A pictorial histopathology atlas that features annotations on tuberculosis. It covers the manifestations of induced or acquired pulmonary tuberculosis in one of six animal species (models) - human, non-human primate, rabbit, guinea pig, rat, and mouse. It also provides low, medium, and high power microscopy views of lung tissue.
Drug Discovery for Neglected Diseases of the Developing World, P. Herrling
Background
The Drug Discovery Process
Therapeutic Tools
Drug Discovery Phases
Phase I-Phase IIa
Phase IIb-Phase III
References
Tuberculosis Biology and Drug Discovery, T. Dick
Disease Manifestations and Treatment
A Largely Unment Medical Need
The Challenge of TB Drug Discovery
An At las for TB Drug Discovery
References
Immunopathology of Tuberculosis Disease across Species, V. Dartois
Overview of Species Specific Characteristics
A Macroscopic View of TB-Infected Lungs across Species
Summary and Lessons Learned
References
Anatomy and Histology of the Human Lung, F.J.W.-M. Leong and A. S.-Y. Leong
Gross Structure
Microscopic Structure
References
Pathology of Tuberculosis in the Human Lung, F.J.W.-M. Leong, S. Eum, L.E. Via, and C.E. Barry, 3rd
Introduction
Features
Variations
References
Pulmonary Tuberculosis in Monkeys, J.L. Flynn and E. Klein
Introduction
Inoculum and Route of Infection
Features
Variations
Strengths of This Animal Model
Shortcomings
References
Pulmonary Tuberculosis in the Rabbit, G. Kaplan and L. Tsenova
Introduction
Inoculum and Route of Inoculation
Features
Strengths of This Animal Model
Shortcomings
References
Pulmonary Tuberculosis in the Guinea Pig, R.J. Basaraba and I.M. Orme
Introduction
Inoculum and Route of Inoculation
Features
Strengths of This Animal Model
Shortcomings
References
Pulmonary Tuberculosis in the Rat, A. Singhal, E.M. Aliouat, C. Creusy, G. Kaplan, and P. Bifani
Introduction
Inoculum and Route of Inoculation
Features
Variations
Strengths of This Animal Model
Shortcomings
References
Pulmonary Tuberculosis in the Mouse, S. Bharath and V. Balasubramanian
Introduction
Inoculum and Route of Inoculation
Features
Variations
Strengths of This Animal Model
Shortcoming
References
Glossary
Index