Energy Metabolism & Lifespan Determination

Considers how lifespan and healthspan can be extended through knowledge of energy metabolism with the experimental model of dietary restriction being one example. The information in this volume of ACAG fosters novel approaches and experiments for further understanding the roles of energy metabolism in aging and disease.

1. The search for energy: A driving force in evolution and aging (M.P. Mattson). 2. Insulin signaling, glucose metabolism oxidative stress and aging (F.S. Facchini). 3. Oxidative phosphorylation, mitochondrial proton cycling, free-radical production and aging (J.R. Speakman). 4. Protein turnover, energy metabolism, aging and caloric restriction (S.R. Spindler). 5. Cellular and molecular mechanisms whereby dietary restriction extends healthspan: A beneficial type of stress (M.P. Mattson). 6. Mitochondrial oxidative stress and caloric restriction (G. Barja, R. Gredilla). 7. Understanding the aging fly through physiological genetics (F. Missirlis). 8. Metabolism and lifespan determination in C. elegans (J. Vanfleteren). 9. Electron transport and lifespan in C. elegans (N. Ishii). 10. Cellular glucose sensing, energy metabolism and aging in Saccharomyces Cerevisiae (J.I. Gordon).