This book summarizes the current state of movement disorder management and the role of surgical therapies as an alternative to medication. Following a chapter on the history of movement disorder surgery, leaders in their fields describe the pathophysiology, functional neuroanatomy, clinical presentation, and medical management of Parkinson's disease, dystonia, and essential tremor. This is followed by chapters on the spectrum of movement disorder surgery itself, from the lesioning procedures of radiofrequency ablation, stereotactic radiosurgery, and high-frequency ultrasound to the modulatory procedures of "asleep", image-guided deep brain stimulation (DBS) and "awake", microelectrode-guided DBS. The final chapters focus on closed-loop DBS, drug-delivery, gene
After years of stagnation, much has been happening in the diagnosis and treatment of kidney diseases. This book contains a comprehensive review of the main developments in AKI, CKD, hemodialysis and kidney transplantation. The section on AKI deals with the key innovations in extracorporeal technologies. The section on nephrology and CKD concentrates on mineral metabolism alterations, restenosis in hemodialytic fistulas, mycophenolate mofetil as an alternative treatment for IgA nephropathy, and the genetics and progression of autosomal dominant polycystic kidney disease. The part on hemodialysis includes contributions on expanded hemodialysis, potassium profiling and home hemodialysis. Chapters on the treatment of acute antibody-mediated rejection after
During recent years, the influence of the immune system and xenobiotic metabolism on the pathogenesis of skin diseases has become evident. This can be observed in disorders such as atopic diseases and atopic dermatitis, psoriasis, skin tumors as well as extrinsic skin aging. Consequently, researchers from the fields of dermatology, environmental research and toxicology have joined in a meeting to advance the interdisciplinary translational research. Highlights are published as original papers or reviews in this special topic issue. The contributions written by renowned experts discuss topics ranging from photoprotection beyond ultraviolet radiation to porphyria, and from actinic keratosis and nanocarriers to cytochrome P450 isoenzymes. To clinicians and researchers in
The gut not only represents the largest endocrine organ of the human body but is also profoundly involved in the control of metabolism through peptide hormones. Therefore, gastrointestinal hormones are acting via autocrine, paracrine, and classical endocrine pathways and regulate e.g. digestion, hunger, and satiety. Furthermore, they are important regulators of body weight, growth, and glucose metabolism, as well as of mood and behavior. Physicians and scientists in the field of pediatric endocrinology and diabetes, as well as in pediatric gastroenterology, require an extensive understanding of the origin of enteroendocrine cells, factors controlling their differentiation, hormone gene expression, secretion, function and, finally, the complex interaction with other
Presenting current knowledge regarding the relationship between exercise and diabetes, this publication discusses in detail the physiologic, molecular and genetic mechanisms involved in this interaction. Further, the book presents valuable information on the role of exercise in the treatment and management of diabetes through the life course, including gestational diabetes, diabetes in children, and in the elderly. Notably, the role of diet in modulating the relationship between exercise and diabetes is explored, and for the first time, the importance of sedentary behavior, rather than exercise, is highlighted. The current public health guidelines for type 2 diabetes are presented, as well as practical recommendations for the management of type 1 diabetes. Finally, in
This volume, written by renowned experts, provides complete coverage of the main genetic conditions associated with diabetes. Divided into five sections, it offers insights into genetic defects involving the pancreatic beta cell, extreme insulin resistance, ciliopathies, obesity and glucose metabolism, chromosomal defects, and other genetic conditions associated with increased susceptibility to diabetes. Other topics include the various subtypes of monogenic diabetes, such as the neonatal form and the Wolfram syndrome, as well as chromosomal defects leading to complex conditions affiliated with diabetes, like Trisomy 21 or Prader-Willi syndrome. There are also chapters dedicated to the poorly explored relationships between metabolism and neurodegenerative disorders
The 1997 classification of diabetes mellitus, now accepted worldwide, includes a large section of 'Other specific types of diabetes', a good part of which is made up of diabetes secondary to other endocrine or pancreatic disorders. However, a comprehensive overview on how these disorders may lead to diabetes, and how to diagnose and treat them, was not available so far. Filling this gap, this book includes detailed descriptions of glucose metabolism derangements in other endocrine and pancreatic disorders. Leading experts in their fields present an exhaustive overview of the most-updated evidence on the etiopathological mechanisms underlying the development of diabetes in patients with endocrine and pancreatic disorders, and the relevant diagnostic and therapeutic
Die Diagnose einer Diabeteserkrankung bedeutet für Betroffene oft einen tiefen Eingriff ins Leben und viele Umstellungen in Ernährung und Alltag. Dass sich daraus nicht zwingend eine grosse Einbusse an Lebensqualität ergeben muss, versucht dieses Buch darzulegen, wobei es - reich an Ratschlägen, Tipps und mit einem praktischen Fragekatalog ausgestattet - selbst einen grossen Beitrag zur Verbesserung der Lebenslage von Diabetes-Betroffenen leisten will. In zwei Hauptteilen wird zunächst alles Wissenswerte über die Krankheit selber erklärt und dann im Besonderen auf das Problem der Ernährung eingegangen. Handlichkeit, verständliche Sprache und viele hilfreiche Abbildungen sollen das Buch für betroffene Leser zu einem brauchbaren und informativen Begleiter durch die
Diabetic retinopathy (DR), a common microvascular complication, has consistently been shown to be associated with an increased risk of cardiovascular disease (CVD). This book provides complete coverage of DR as a potential marker for CVD in those with diabetes. It succinctly reviews the epidemiological and pathogenic links of DR to various cardiovascular events including stroke, coronary artery disease, chronic kidney disease, heart failure, and mortality. Furthermore, it discusses the usefulness of DR in CVD risk prediction and cardiovascular safety of anti-VEGF therapy in diabetic patients. There are insights from contemporary diabetic trials that demonstrated the enhanced cardiovascular benefit of novel glucose lowering therapy. It also highlights the potential of
It is well known that acute, severe hyponatremia is a life-threatening situation. However, there is growing evidence that mild and chronic hyponatremia may also have negative consequences. Gait disturbances, attention deficits, falls and fractures, and bone loss have all been reported, with increased mortality in almost every disease state if the patient is hyponatremic. This book has been written by key opinion leaders in the field and covers a spectrum of crucial aspects of hyponatremia, including a historical perspective, physiology and pathophysiology of water homeostasis, epidemiology of hyponatremia, and clinical features. A detailed description of all available therapies has been incorporated, with a guide to a clinician's approach to key therapeutic
Despite constant significant advances, cardiovascular as well as more general outcomes of hemodialysis treatment remain unsatisfactory. The introduction of innovative 'high retention onset' membranes has led to the development of a new treatment modality called 'expanded hemodialysis' (HDx), which is the focus of this book. This new therapy is likely to benefit end-stage kidney disease patients, thanks to enhanced removal of molecules retained by current dialysis techniques. HDx is simple to set up and application does not require special hardware or specific nursing skills. This book contains emerging evidence and fascinating new hypotheses on HDx. It is highly recommended for all physicians and healthcare professionals who are caring for dialysis patients and are
Acute pancreatitis (AP) is one of the most common disorders of the gastrointestinal tract to result in hospitalization. Although most patients with AP will experience an uneventful disease course, those that develop moderate-to-severe AP can be challenging to manage. Rapid recognition, accurate diagnosis and prediction of severity, together with appropriate treatment, are therefore key in achieving the best outcomes for patients and for preventing subsequent episodes of AP. Written by two pancreatologists with extensive experience of managing patients with AP as well as in clinical research, 'Fast Facts: Acute and Recurrent Pancreatitis' provides a comprehensive, evidence-based guide to: - The pathophysiology and etiology of AP - Fundamentals of diagnosis -
'Fast Facts: Advanced Cutaneous Squamous Cell Carcinoma' is for people who have or may have advanced cutaneous squamous cell carcinoma. It aims to help patients, and people close to them, understand the condition so they can have better discussions with the cancer team. Decisions about treatment and next steps are highly individual. They will depend on the site and features of the person's cancer as well as their general health. With its clear text and diagrams, this booklet can help the patient understand how the cancer develops and the tests and treatments that may be recommended. And with boxes and prompts for the reader's own notes and questions, 'Fast Facts: Advanced Cutaneous Squamous Cell Carcinoma' can become a truly personalized resource.
Autor:Andrea Coravos
Camille Nebeker
Daniel Karlin
Eric Perakslis
Jennifer Goldsack
Kelley Erb
Noah Zimmerman
Data wydania:2020
Technology is changing how we practice medicine. Sensors and wearables are getting smaller and cheaper, and algorithms are becoming powerful enough to predict medical outcomes. Yet despite rapid advances, healthcare lags behind other industries in truly putting these technologies to use. A major barrier is the cross-disciplinary approach required to create digital tools, a process that requires knowledge from many people across a range of fields. 'Fast Facts: Digital Medicine - Measurement' aims to overcome that barrier, introducing the reader to core concepts and terms and facilitating dialogue. Contrasting 'clinical research' with routine 'clinical care', this short colorful book describes types of digital measurement and how to use and validate digital measures in
The menopause transition affects different women in different ways, with symptoms ranging from mild to debilitating. This fact-filled workbook explains in simple language what happens during the perimenopausal years, highlights the long-term consequences of the menopause, and debunks the myths surrounding menopausal hormone treatment. With spaces to write notes and keep track of symptoms, it is the ideal resource to help women have informed discussions with their doctors or nurses and choose how they want to manage their menopause transition. Contents: * What is the menopause? * What's happening with my hormones? * How will the menopause transition affect me? * Long-term consequences of the menopause * Managing the common symptoms * Sex and the menopause * Lifestyle
In den letzten Jahren kam es zu einem noch nie dagewesenen Anstieg unseres Wissens uber das Management des Ovarialkarzinoms; von Diagnose und Genetik bis hin zur Operation und neuen zielgerichteten Behandlungsmethoden. Das bedeutet, dass sich fur den gut informierten Mediziner in Bezug auf die Diagnose und Behandlung von Frauen mit Ovarialkarzinom oder dem Verdacht auf Ovarialkarzinom mehrere Moeglichkeiten zur sinnvollen Intervention bieten. Dieses Buch bietet eine umfassende UEbersicht uber alle Versorgungsebenen, fasst die aktuellen Fortschritte zusammen und stellt sie in klinischen Kontext. Es beantwortet wichtige Fragen, wie wann operiert werden und wann eine Behandlung mit konventionellen bzw. mit neuartigen Modalitaten durchgefuhrt werden sollte. Inhalt: *
This is the tenth edition of this Fast Facts handbook since the first was published in 1996 - the many iterations are testament to the rapid changes in the field and steadily improving outlook for patients. This new edition introduces the Gleason grade grouping (Chapter 1), which has important prognostic value, and nomograms that are used to evaluate risk (Chapter 3). Our understanding of the genetics and underlying pathogenesis of prostate cancer is growing apace, leading to the identification of germline mutations and the development of genomic tests to help identify and direct therapy for those at greatest risk of developing clinically significant disease. They also provide reassurance for those patients who have opted for active surveillance (Chapters 3 and 5).
Thrombotic thrombocytopenic purpura (TTP) is a rare disorder of the blood coagulation system. In most cases, a lack of the ADAMTS13 enzyme leads to an accumulation of ultra-large von Willebrand factor molecules in the plasma which, in turn, initiate the formation of microscopic thromboses in small blood vessels. TTP is a medical emergency. Timely diagnosis and urgent and effective management are vital - mortality in those untreated is in the region of 90%. The understanding of TTP pathogenesis has increased markedly in recent decades. It is now known that TTP is acquired (immunemediated) or congenital, and that the most common type - the acquired form - predominantly affects women in their 40s. It is also clear that the prompt delivery of plasma exchange saves lives.
This book focuses on a crucial moment in human life: the introduction of solid foods to the diet during late infancy and early childhood. The impact on health and development as well as the long-term effects and prevention of disease are analyzed by a panel of leading international experts. The immediate consequences of solid foods on the health of toddlers are studied with regard to allergic diseases, diarrhea and constipation. The late effects of weaning habits, such as obesity, diabetes, and the early influences on taste preferences are also dealt with in this publication. Each of the topics is introduced by a chapter on physiology, followed by further contributions on major clinical aspects. Finally the book offers educational recommendations for industry,
Autor:C. S. Walther
C.S. Walther
H. A. Domanski
H.A. Domanski
Data wydania:2017
Fine-needle aspiration cytology (FNAC) has been commonly used to follow up on previously treated sarcomas or to confirm soft tissue and bone metastases of carcinomas, melanomas or lymphomas. Its role as the first-line approach in the diagnosis of primary soft tissue and bone tumors has increased due to progress of less invasive diagnostic procedures and the growing availability of diagnostic ancillary tests. This comprehensive and richly-illustrated volume presents cytomorphology of all common neoplastic soft tissue and bone lesions but also of rare tumors largely described in case reports. Key points for cytological features, differential diagnosis, and the use of ancillary tests are discussed and illustrated in order to facilitate the diagnostic work-up in FNA
This unique publication was written by experts who have made significant contributions to the development of reconstructive microsurgery and vascularized composite allotransplantation and are likely to shape its future. The book is divided into three major sections. The first presents the state-of-the-art of autologous microsurgical reconstruction. It summarizes current achievements, highlights the shortcomings of currently available techniques, and prepares the reader for the next evolutionary step: allotransplantation. Section two is a comprehensive review of allotransplantation, from immunology to surgical techniques. Finally, for those interested in establishing a comprehensive center for vascularized composite allotransplantation, section three provides important
Over the past decade, there has been unprecedented progress in our understanding of the genetic basis of type 2 diabetes driven largely by technological advances which have facilitated genome-wide studies. Bringing together comprehensive synopses written by leaders in the field, this book discusses the recent progress in defining the genetic basis for type 2 diabetes and related traits. The opening section focuses on the impact of genome-wide association studies on our understanding of the genetic landscape of type 2 diabetes, whilst later chapters explore how variants affecting relevant metabolic traits influence diabetes susceptibility. The impact of next-generation sequencing on gene discovery efforts in both type 2 diabetes and mendelian forms of diabetes and
Malnutrition among children remains a persistent problem around the world. This publication aims to map the challenges within the global landscape of childhood nutrition and considers the importance of nutrition both prior to conception and in children beyond two years of age. Session I provides an updated picture of malnutrition around the world, the recent progress that has been made in eliminating malnutrition in all its forms and several data limitations to track such progress. The role of milk in early life is covered in session II. The chapters describe different aspects of cow's milk and the possible role of optimized plant proteins as an alternative to dairy ingredients in treating children with severe acute malnutrition. Session III considers the ramifications
Malnutrition caused by deficiencies of vitamins and minerals - also called hidden hunger - impairs both the intellectual and physical development of a child. Due to the absence of clinical symptoms and assessments, no intervention can be staged. The tragedy is that this, in turn, decreases the child's chance to escape from poverty. This book looks at malnutrition in high-income countries, the nutrition transition and nutritional deficiencies in low-income countries, consequences of hidden hunger, and interventions to improve nutrition security. Written by leading experts in the field, it clearly stresses that national governments and international organizations must make malnutrition one of their top priorities in order to provide children with optimal conditions
